Sal J. Caradonna, Ph.D.
Chairman
E-mail: caradonn@umdnj.edu
Phone: 856 566-6056
Fax: 856 566-6232
Office: Science Center 120
Address:
Department of Molecular Biology
UMDNJ-SOM
2 Medical Center Drive
Stratford, NJ 08084

RESEARCH

DNA repair, cell-cycle regulatory pathways and apoptotic mechanisms induced by aberrant DNA repair mechanisms.

Recent Publications:

Jennifer A. Fischer, Susan Muller-Weeks and Salvatore J. Caradonna.  Fluorodeoxyuridine Modulates Cellular Expression of the DNA Base Excision Repair Enzyme Uracil-DNA Glycosylase.  Cancer Research 66, 8829-8837, September 1, 2006.

Muller-Weeks, S., Balzer, R.J., Anderson, R. and Caradonna, S. Proliferation-dependent expression of nuclear uracil-DNA glycosylase is mediated in part by E2F-4.  DNA Repair, Vol. 4, Issue 2, 183-190, 2005.

Fischer, J.A., Muller-Weeks, S., Caradonna, S. Proteolytic Degradation of the Nuclear Isoform of Uracil-DNA Glycosylase Occurs During the S Phase of the Cell Cycle.  DNA Repair: 3, 505-513, 2004.

Elateri, I., Muller-Weeks, S. and Caradonna, S.  The Transcription Factor, NFI/CTF Plays a Positive Regulatory Role in Expression of the hSMUG1 Gene DNA Repair 2:  1371-1385, 2003.

Elateri, I., Tinkelenberg, B.A., Hansbury, M., Caradonna, S., Muller-Weeks, S. and Ladner, R.D., hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae. DNA Repair 2:315-323, 2003.

Caradonna, S. and Muller-Weeks, The Nature of Enzymes Involved in Uracil-DNA Repair: Isoform Characteristics of Proteins Responsible for Nuclear and Mitochondrial Genomic Integrity. Current Protein and Peptide Science 2:335-347, 2001

Ladner, R.D., Lynch, F.J., Groshen, S., Xiong, Y.P., Sherrod, A., Caradonna, S.J., Stoehlmacher, J. and Lenz, H.J. dUTPase Isoform Expression in Normal and Neoplastic Tissues: Association with Survival and Response to 5-FU in Colorectal Cancer. Cancer Research 60: 3493-3503, 2000

M. B. Dabrow, D.O., M. R. Francesco, M.S. F.X. McBrearty, M.D. And S.J. Caradonna, Ph.D. The Effects of Platelet-Derived Growth Factor and Receptor on Normal and Neoplastic Human Ovarian Surface Epithelium. Gynecologic Oncology 71:  29-37, 1998

Muller-Weeks, S. J., Mastran, B. and Caradonna, S. Identification of a Novel Isoform of the Highly Conserved Human Uracil-DNA Glycosylase, J. Biol. Chem. 273: 21909-21917, 1998